Product Name:

NebuSelect™ Recombinant Human CD45/PTPRC, His-tag

Catalog#:

NBL-242172

Description:

NebuSelect™ Recombinant Human CD45/PTPRC, His-tag(Cat#NBL-242172) is expressed in HEK293 with His tag at the C-Terminus.It contains Gln26-Lys577.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 61.9 kDa. Due to glycosylation, the protein migrates to 118-150 kDa based on Bis-Tris PAGE result.

Target Name:

CD45/PTPRC; L-CA; CD45; T200; PTPRC; B220; CD45R; GP180; LCA; LY5; EC 3.1.3.48

Target Information:

PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts.

Amino Acid Sequence: 

Gln26-Lys577

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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