Product Name:

NebuSelect™ Recombinant Human EGFRVIII, Avi-His-tag

Catalog#:

NBL-240769

Description:

NebuSelect™ Recombinant Human EGFRVIII, Avi-His-tag(Cat#NBL-240769) is expressed in HEK293 with His tag and Avi tag at the N-Terminus.It contains Leu25-Ser378.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 68-80 kDa based on Bis-Tris PAGE result.

Target Name:

EGFRVIII; ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2

Target Information:

The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand.

Amino Acid Sequence: 

Leu25-Ser378

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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