Product Name:

NebuSelect™ Recombinant Human TREM2, hFc-tag

Catalog#:

NBL-240827

Description:

NebuSelect™ Recombinant Human TREM2, hFc-tag(Cat#NBL-240827) is expressed in HEK293 with hFc tag at the C-Terminus.It contains His19-Ser174.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 44.2 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.

Target Name:

TREM2; PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c

Target Information:

TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2- consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.

Amino Acid Sequence: 

His19-Ser174

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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