Product Name:

NebuSelect™ Recombinant Human EPHA4, His-tag

Catalog#:

NBL-240873

Description:

NebuSelect™ Recombinant Human EPHA4, His-tag(Cat#NBL-240873) is expressed in HEK293 with His tag at the C-Terminus.It contains Val20-Thr547.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 59.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

Target Name:

EPHA4; Sek; Sek1; EphA4; HEK8; SEK; TYRO1; EK8

Target Information:

The expression and activation of EphA4 in the various cell types in a knee joint was upregulated upon an intraarticular injury. To determine if EphA4 signaling plays a role in osteoarthritis, we determined whether deficient EphA4 expression (in EphA4 knockout mice) or upregulation of the EphA4 signaling (with the EfnA4-fc treatment) would alter cellular functions of synoviocytes and articular chondrocytes. In synoviocytes, deficient EphA4 expression enhanced, whereas activation of the EphA4 signaling reduced, expression and secretion of key inflammatory cytokines and matrix metalloproteases.

Amino Acid Sequence: 

Val20-Thr547

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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