Product Name:

NebuSelect™ Recombinant Mouse&Human Chimeric Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His-tag

Catalog#:

NBL-241161

Description:

NebuSelect™ Recombinant Mouse&Human Chimeric Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His-tag(Cat#NBL-241161) is expressed in HEK293 with His tag at the C-terminus.It contains Phe31-Val988 (ITGAV) acidic tail and Gly22-Asn707 (ITGB6) basic tail.

Species:

Mouse&Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 131.48 kDa (ITGAV) and 79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 120-160 kDa (ITGAV) and 90-120 kDa (ITGB6) based on Bis-Tris PAGE result.

Target Name:

Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer

Target Information:

ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.

Amino Acid Sequence: 

Phe31-Val988 (ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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