Product Name:

NebuSelect™ Recombinant Biotinylated Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer , Avi-His-tag

Catalog#:

NBL-241263

Description:

NebuSelect™ Recombinant Biotinylated Human Integrin alpha 6 beta 1 (ITGA6&ITGB1) Heterodimer , Avi-His-tag(Cat#NBL-241263) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe24-Gly1012 (ITGA6) acidic tail and GIn21-Asp728 (ITGB1) basic tail.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 117.9 kDa (ITGA6) and 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-160 kDa (ITGA6) and 110-150 kDa (ITGB1) under Non reducing (N) condition based on Bis-Tris PAGE result.

Target Name:

Integrin ITGA6&ITGB1 Heterodimer

Target Information:

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling

Amino Acid Sequence: 

Phe24-Gly1012 (ITGA6) acidic tail & GIn21-Asp728 (ITGB1) basic tail

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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