Product Name:

NebuSelect™ Recombinant Cynomolgus ALK-1/ACVRL1, His-tag

Catalog#:

NBL-241372

Description:

NebuSelect™ Recombinant Cynomolgus ALK-1/ACVRL1, His-tag(Cat#NBL-241372) is expressed in HEK293 with His tag at the C-Terminus.It contains Asp22-Gln118.

Species:

Cynomolgus

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 11.86 kDa. Due to glycosylation, the protein migrates to 25-35 kDa based on Bis-Tris PAGE result.

Target Name:

ALK-1/ACVRL1

Target Information:

Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence.

Amino Acid Sequence: 

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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