Product Name:

NebuSelect™ Recombinant Mouse Noggin, hFc-tag

Catalog#:

NBL-241397

Description:

NebuSelect™ Recombinant Mouse Noggin, hFc-tag(Cat#NBL-241397) is expressed in HEK293 with hFc tag at the C-terminus.It contains Gln28-Cys232.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 49.83 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.

Target Name:

Noggin

Target Information:

Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt.

Amino Acid Sequence: 

Gln28-Cys232

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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