Product Name:

NebuSelect™ Recombinant Mouse Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His-tag

Catalog#:

NBL-241805

Description:

NebuSelect™ Recombinant Mouse Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His-tag(Cat#NBL-241805) is expressed in HEK293 with His tag at the C-Terminus.It contains Phe29-Pro1141(ITGA1) acidic tail&Gln21-Asp728(ITGB1) basic tail.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 129.00 kDa (ITGA1)&82.80 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-200 kDa (ITGA1) and 100-115 kDa (ITGB1) based on Bis-Tris PAGE result.

Target Name:

Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer

Target Information:

Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.

Amino Acid Sequence: 

Phe29-Pro1141(ITGA1)acidic tail & Gln21-Asp728(ITGB1)basic tail

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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