Product Name:

NebuSelect™ Recombinant Mouse WISP1, His-tag

Catalog#:

NBL-241947

Description:

NebuSelect™ Recombinant Mouse WISP1, His-tag(Cat#NBL-241947) is expressed in HEK293 with His tag at the C-Terminus.It contains Thr23-Asn367.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 39.4 kDa. Due to glycosylation, the protein migrates to 64-68 kDa based on Bis-Tris PAGE result.

Target Name:

WISP1; ELM-1; WISP-1; CCN4; WISP1c; WISP1i; WISP1tc

Target Information:

The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.

Amino Acid Sequence: 

Thr23-Asn367

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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