Product Name:

NebuSelect™ Recombinant Human TYRO3, His-tag

Catalog#:

NBL-241970

Description:

NebuSelect™ Recombinant Human TYRO3, His-tag(Cat#NBL-241970) is expressed in HEK293 with His tag at the C-Terminus.It contains Ala41-Trp429.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 42.8 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

Target Name:

TYRO3; BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse

Target Information:

The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.

Amino Acid Sequence: 

Ala41-Trp429

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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