Product Name:

NebuSelect™ Recombinant Mouse TMEM106B, hFc-tag

Catalog#:

NBL-242045

Description:

NebuSelect™ Recombinant Mouse TMEM106B, hFc-tag(Cat#NBL-242045) is expressed in HEK293 with hFc tag at the C-Terminus.It contains Pro119-Gln275.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 44.8 kDa. Due to glycosylation, the protein migrates to 65-68 kDa based on Bis-Tris PAGE result.

Target Name:

TMEM106B; Transmembrane protein 106B；Tmem106b

Target Information:

TMEM106B is a well-recognised risk factor for FTD caused by GRN mutation. Elegant experiments have suggested that increased risk for FTD is due to elevated levels of TMEM106B (Nicholson et al, 2013; Gallagher et al, 2017). Therefore, recent work has explored the therapeutic potential of reducing TMEM106B levels, with initial results looking encouraging, as crossing a Grn-deficient mouse to a Tmem106b knockout showed a rescue in FTD-related behavioural defects and specific aspects of lysosome dysfunction (Klein et al, 2017).

Amino Acid Sequence: 

Pro119-Gln275

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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