Product Name:

NebuSelect™ Recombinant Human RGMa, Avi-His-tag

Catalog#:

NBL-242164

Description:

NebuSelect™ Recombinant Human RGMa, Avi-His-tag(Cat#NBL-242164) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Cys48-Gly422.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 44.5 kDa. Due to glycosylation, the protein migrates to 45-48 kDa based on Bis-Tris PAGE result.

Target Name:

RGMa; RGMA; RGM

Target Information:

Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to its receptor neogenin regulates axon guidance, neuronal differentiation, and survival during the development of the CNS. RGMa induces T cell activation in experimental autoimmune encephalomyelitis (EAE), which is the animal model of multiple sclerosis (MS).- RGM is expressed in pathogenic Th17 cells and induces neurodegeneration by binding to neogenin.

Amino Acid Sequence: 

Cys48-Gly422

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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