Product Name:

NebuSelect™ Recombinant Human Kallikrein 5/KLK5, His-tag

Catalog#:

NBL-242398

Description:

NebuSelect™ Recombinant Human Kallikrein 5/KLK5, His-tag(Cat#NBL-242398) is expressed in HEK293 with His tag at the C-Terminus.It contains Val23-Ser293.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 30.7 kDa. Due to glycosylation, the protein migrates to 42-48 kDa based on Bis-Tris PAGE result.

Target Name:

Kallikrein 5/KLK5; Kallikrein c; Klnc; KLK5; KLKL2; KLK-L2; SCTE

Target Information:

The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches.

Amino Acid Sequence: 

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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