Product Name:

NebuSelect™ Recombinant Mouse GEP, His-tag

Catalog#:

NBL-242592

Description:

NebuSelect™ Recombinant Mouse GEP, His-tag(Cat#NBL-242592) is expressed in HEK293 with His tag at the C-Terminus.It contains Thr18-Leu589.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 62.7 kDa. Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.

Target Name:

GEP; Progranulin; PGRN; Acrogranin; GP88; Glycoprotein 88; PCDGF; PEPI; CLN11; GEP; Granulin; GRN

Target Information:

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). Loss of PGRN leads to lysosome dysfunction during aging. TMEM106B, a gene encoding a lysosomal membrane protein, is the main risk factor for FTLD with PGRN haploinsufficiency.Loss of both PGRN and TMEM106B results in an increased accumulation of lysosomal vacuoles in the axon initial segment of motor neurons and enhances the manifestation of FTLD phenotypes with a much earlier onset.

Amino Acid Sequence: 

Thr18-Leu589

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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