Product Name:

NebuSelect™ Recombinant Biotinylated Cynomolgus GARP&Latent TGF beta 1 Complex, Avi-His-tag

Catalog#:

NBL-242613

Description:

NebuSelect™ Recombinant Biotinylated Cynomolgus GARP&Latent TGF beta 1 Complex, Avi-His-tag(Cat#NBL-242613) is expressed in HEK293 with His tag and Avi tag at the C-Terminus.It contains Ala18-Leu628(GARP)&Leu30-Ser390(Latent TGF beta 1).

Species:

Cynomolgus

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 70.5 kDa (GARP)&41.3 kDa (Latent TGF Beta 1). Due to glycosylation, the protein migrates to 70-80 kDa (GARP)&13 kDa&42-50 kDa (Latent TGF Beta) based on Bis-Tris PAGE result.

Target Name:

GARP&Latent TGF beta 1 Complex; LRRC32; GARP; LAP; TGF-beta-1; LRRC32&TGF-beta 1; LRRC32&TGFB1

Target Information:

GARP&Latent TGF Beta is a complex found on surface of many types of cells. In Tregs, GARP is involved in TCR-mediated activation of Latent TGF-β and thus promoting secretion and activation of TGF-β. Integrin αvβ8 on the surface of immune cells and other cells recognizes RGD in LAP, resulting in the release of mature TGF-β from the TGF-β&GARP complex.

Amino Acid Sequence: 

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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