Product Name:

NebuSelect™ Recombinant Human TRAIL R2/DR5/TNFRSF10B, hFc-tag

Catalog#:

NBL-242736

Description:

NebuSelect™ Recombinant Human TRAIL R2/DR5/TNFRSF10B, hFc-tag(Cat#NBL-242736) is expressed in HEK293 with hFc tag at the C-Terminus.It contains Ile56-Glu182.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 41.1 kDa. Due to glycosylation, the protein migrates to 50-55 kDa based on Bis-Tris PAGE result.

Target Name:

TRAIL R2/DR5/TNFRSF10B; CD262; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRICK2; TRICK2A; TRICKB; ZTNFR9; KILLER

Target Information:

DR5, also called TRAIL R2, TRICK 2, TNFRSF10B, and MK is a type 1 TNF R superfamily, membrane protein which is a receptor for TRAIL (APO2 ligand). DR5 is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Amino Acid Sequence: 

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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