Product Name:

NebuSelect™ Recombinant Human DLL1/Delta1, His-tag

Catalog#:

NBL-242743

Description:

NebuSelect™ Recombinant Human DLL1/Delta1, His-tag(Cat#NBL-242743) is expressed in HEK293 with His tag at the C-Terminus.It contains Gln18-Gly540.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 57.6 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.

Target Name:

DLL1/Delta1; H-Delta-1; DLL1; DELTA1; DL1

Target Information:

DLL1, a Notch signaling ligand, is significantly overexpressed in ERα luminal breast cancer. Intriguingly, DLL1 overexpression correlates with poor prognosis in ERα luminal breast cancer, but not in other subtypes of breast cancer. In addition, this effect is specific to DLL1, as other Notch ligands (DLL3, JAGGED1, and JAGGED2) do not influence the clinical outcome of ERα patients. DLL1-mediated Notch signaling in breast cancer is important for tumor cell proliferation, angiogenesis, and cancer stem cell function.

Amino Acid Sequence: 

Gln18-Gly540

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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