Product Name:

NebuSelect™ Recombinant Mouse AMIGO2, His-tag

Catalog#:

NBL-243111

Description:

NebuSelect™ Recombinant Mouse AMIGO2, His-tag(Cat#NBL-243111) is expressed in HEK293 with His tag at the C-Terminus.It contains Met39-Thr397.

Species:

Mouse

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 41.8 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.

Target Name:

AMIGO2; Amphotein-induced protein 2; AMIGO-2; Alivin-1; DEGA; AMIGO2; ALI1; alivin 1

Target Information:

Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis.

Amino Acid Sequence: 

Met39-Thr397

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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