Product Name:

NebuSelect™ Recombinant Human Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer , His-tag

Catalog#:

NBL-241847

Description:

NebuSelect™ Recombinant Human Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer , His-tag(Cat#NBL-241847) is expressed in HEK293 with His tag at the C-Terminus; It contains Phe17-Asn1104 (ITGAM) acidic tail and Gln23-Asn700 (ITGB2) basic tail.

Species:

Human

Expression System:

HEK293

Molecular Weight: 

The protein has a predicted MW of 126.10 kDa (ITGAM) and 79.50 kDa (ITGB2). Due to glycosylation, the protein migrates to 140-160 kDa (ITGAM) and 90-100 kDa (ITGB2) based on Bis-Tris PAGE result.

Target Name:

Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer

Target Information:

Integrin αMβ2, also called Mac-1 or complement receptor-3 (CR3), is a heterodimer expressed on monocytes. It functions as both an adhesion molecule mediating the diapedesis of leukocytes across the endothelium and a receptor for the iC3b fragment of complement responsible for phagocytic/degranulation responses to microorganisms[1]. Active αMβ2 binds iC3b, coagulation proteins fibrinogen, plasminogen and factor X, extracellular matrix (ECM) proteins fibronectin, laminin and collagen, and cell surface ICAMs, myelin basic protein and DC­SIGN[2].

Amino Acid Sequence: 

Phe17-Asn1104 (ITGAM) acidic tail & Gln23-Asn700 (ITGB2) basic tail

Purity:

＞95%

Formulation:

see COA

Endotoxin:

＜1EU/ug(LAL Method)

Storage: 

4°C for short term. 

-20°C for long term.

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